2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9. doi: 10.1016/j.bmcl.2004.06.085.

Abstract

2-(Anilino)imidazolines were identified as novel human 5-HT(1D) receptor ligands, but offered no particular advantage over previously reported 2-(benzyl)imidazolines. Pharmacokinetic and functional data were obtained for selected 2-(benzyl)imidazoline derivatives.

Publication types

  • Comparative Study

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Aniline Compounds / chemistry
  • Aniline Compounds / pharmacokinetics
  • Aniline Compounds / pharmacology*
  • Animals
  • Benzyl Compounds / chemistry
  • Benzyl Compounds / pharmacokinetics
  • Benzyl Compounds / pharmacology*
  • Humans
  • Imidazolines / chemistry
  • Imidazolines / pharmacology*
  • In Vitro Techniques
  • Ligands
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / physiology
  • Radioligand Assay
  • Rats
  • Receptor, Serotonin, 5-HT1D / metabolism*
  • Saphenous Vein / drug effects
  • Saphenous Vein / physiology
  • Serotonin Receptor Agonists / chemistry
  • Serotonin Receptor Agonists / pharmacokinetics
  • Serotonin Receptor Agonists / pharmacology*
  • Structure-Activity Relationship

Substances

  • Aniline Compounds
  • Benzyl Compounds
  • Imidazolines
  • Ligands
  • Receptor, Serotonin, 5-HT1D
  • Serotonin Receptor Agonists
  • Adenylyl Cyclases